D-mannitol Crystal As Excipient

Mannitol is a hexanol, because it absorbs heat when dissolved, has sweet taste and is comfortable to the mouth, so it is more widely used in the manufacture of chewing tablets such as sobriety medicine and mouth refreshing agent, and its particle type is specially used as excipient for direct pressing tablets. Mannitol is a hyperosmotic tissue dehydrating agent, widely used in clinical treatment of brain edema, prevention of acute renal failure, treatment of glaucoma, accelerate the excretion of toxins and drugs from the kidney.
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Product Details

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Mannitol is a hexanol, because it absorbs heat when dissolved, has sweet taste and is comfortable to the mouth, so it is more widely used in the manufacture of chewing tablets such as sobriety medicine and mouth refreshing agent, and its particle type is specially used as excipient for direct pressing tablets. Mannitol is a hyperosmotic tissue dehydrating agent, widely used in clinical treatment of brain edema, prevention of acute renal failure, treatment of glaucoma, accelerate the excretion of toxins and drugs from the kidney.


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Product Specification:

ItemStandard
Appearancewhite to yellowish powder or particle
Assay (%)99-101
Light Transmittance (%)≥ 96.0
Moisture (%)≤ 0.5
Readily Carbonisablle Substance≤ 1.0
Sulphated Ash (%)≤ 0.05
Chloride (%≤ 0.005
Sulphate (%)≤ 0.01
Oxalate (%)≤ 0.01
Calcium (%)≤ 0.02
Iron (mg/kg)≤ 5
Arsenic (mg/kg)≤ 1
Lead≤0.5
Water Insoluble SubstancesFiltration time not more than 1 min;
Filter membrane basically doesn't change color;
Visual mottled particles not more than 3.
Packing25kg/bag


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Application:

Mannitol is a good diuretic on medicine, reduce intracranial pressure, intraocular pressure and renal medicine, dehydrating agent, sugar substitute, also used as excipient of tablets and solid, liquid diluent. Mannitol injection, as a hyperosmotic antihypertensive drug, is a commonly used drug in clinical rescue, especially in the rescue of brain diseases. It has the characteristics of rapid hypotensive reduction and accurate curative effect required by drugs to reduce intracranial pressure. As an excipient for tablets, mannitol has no hygroscopic properties, fast drying, good chemical stability, and has the characteristics of crisp, good granulation, etc. It is used in most tablets such as anti-cancer drugs, antimicrobial drugs, antihistamines and vitamins. In addition, it is also used for sobriety medicine, mouth refreshing agent and other mouth chewing tablets. In terms of food, the water absorption of the product in sugar and sugar alcohol is the least, and has a refreshing sweet taste, used for maltose, chewing gum, rice cakes and other food anti-stick, as well as used for general pastry anti-stick powder. Can also be used as diabetes patients with food, fitness food and other low calorific value, low sugar sweetener. In industry, mannitol can be used in plastic industry, rosin ester and artificial glycerin resin, explosives, detonators (nitrifying mannitol) and so on. In chemical analysis for the determination of boron, biological test as a bacterial culture agent. Although mannitol can be absorbed by the stomach and intestines, it does not accumulate in the body. After absorption, part is metabolized in the body, and the other part is excreted in the urine; Dibromomannitol can be prepared by the reaction of hydrobromic acid.
Used in the synthesis of resins and drugs; Dehydrating drugs, diuretics. Treatment of brain edema and glaucoma, acute oliguria, prevention of acute renal failure, treatment of nephrotic syndrome edema. Injection is forbidden for patients with active intracranial hemorrhage (except for craniotomy)

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